Method for testing samples containing prion protein for the possible presence of the prpsc form

The invention relates to a method for testing samples containing prion protein for the possible presence of the PrP Sc form, according to which: (Step a) the sample is mixed with protease in order to digest protease-sensitive proteins or protein regions; (Step b) after digestion, it is tested whether the sample contains the region PrP 27-30 of the prion protein, which is resistant in the PrP Sc form of the prion protein protease, and the presence of PrP Sc in the sample is established based on the positive detection of PrP 27-30. The inventive method is characterized in that, during Step b, the sample is additionally tested in order to determine whether a complete digestion of the protease-sensitive region of the prion protein has occurred.