Oxindoles which are inhibitors of CDK-1 and their application in therapeutics

The present invention relates to a compound of formula (I): 1 wherein R5 is selected from the group consisting of 3-pyridyl, 5-pyrimidinyl, -CONH-(C 1 -C 4 alkyl), -NHCO-(C 1 -C 4 alkyl), halogen, -SO 2 NH 2 , -NO 2 , -CF 3 or thien-2-ylcarbonyl 2 and -CO 2 R where R can be hydrogen or C 1 -C 4 alkyl; and Ar is selected from the group consisting of 5-imidazolyl, 2-pyrrolyl optionally substituted by a C 1 -C 4 alkyl radical, 2-furyl or 2-thiazolyl, in the E or Z geometrical isomeric form or a mixture of the two geometrical isomeric forms. The invention is also directed to a method of treating primary and secondary tumours in a patient in need thereof comprising administering to the patient a therapeutically effective amount of a compound of formula I. The invention is also directed to a method of using a compound of formula I to treat cancer, inhibit the proliferation of a cell and induce cell apoptosis, comprising contacting a cell with an effective amount of the compound of formula I., The invention is also directed to a method of preparing the compound of formula I.