Production method of 1-substituted-1,2,3-triazole derivatives

A method for producing a compound of the formula: 1 by reacting 2 (1) in a secondary or tertiary alcohol in the presence of a base, or (2) in the absence of a base is provided. According to this method, a 1-substituted-1,2,3-triazole compound having a tyrosine kinase inhibitory action can be produce...

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Hauptverfasser: Ikemoto, Tomomi, Ito, Tatsuya, Tomimatsu, Kiminori, Sawai, Yasuhiro, Nishiyama, Hirohiko, Isogami, Yasushi
Format: Patent
Sprache:eng
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Zusammenfassung:A method for producing a compound of the formula: 1 by reacting 2 (1) in a secondary or tertiary alcohol in the presence of a base, or (2) in the absence of a base is provided. According to this method, a 1-substituted-1,2,3-triazole compound having a tyrosine kinase inhibitory action can be produced efficiently in a high yield at an industrial large scale by a convenient method