Substituted bezopyran derivatives for the treatment of inflammation

Substituted bezopyran derivatives for the treatment of inflammation

A class of benzopyrans, benzothiopyrans, dihydroquinolines, dihydronaphthalenes, and analogs thereof, is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I′ 1 wherein X, A 1 , A 2 , A 3 , A 4 , R, R″, R 1 and R 2 are as descri...

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Hauptverfasser: Obukowicz, Mark, Carter, Jeffery, Devadas, Balekudru, Talley, John, Brown, David, Graneto, Matthew, Bertenshaw, Stephen, Rogier, Donald, Nagarajan, Srinivasan, Hanau, Cathleen, Hartmann, Susan, Ludwig, Cindy, Metz, Suzanne, Korte, Donald
Format: Patent
Sprache:eng
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Zusammenfassung:A class of benzopyrans, benzothiopyrans, dihydroquinolines, dihydronaphthalenes, and analogs thereof, is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I′ 1 wherein X, A 1 , A 2 , A 3 , A 4 , R, R″, R 1 and R 2 are as described in the specification.