Interleukin converting enzyme inhibitors

Interleukin converting enzyme inhibitors

The present invention relates to novel compounds, compositions comprising said compounds, and uses thereof, said compounds having the formula: 1 wherein each X is independently selected from: i) -C(W) 2 -; ii) -C(O)-; iii) -NR 2 -; iv) -S-; v) -S(O)-; vi) -S(O) 2 -; vii) two units, one from each adj...

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Bibliographische Detailangaben
Hauptverfasser: Wang, Yili, Wos, John, Oppong, Kofi, O'Neil, Steven, Laufersweiler, Michael, Soper, David, De, Biswanath, Demuth, Thomas
Format: Patent
Sprache:eng
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Zusammenfassung:The present invention relates to novel compounds, compositions comprising said compounds, and uses thereof, said compounds having the formula: 1 wherein each X is independently selected from: i) -C(W) 2 -; ii) -C(O)-; iii) -NR 2 -; iv) -S-; v) -S(O)-; vi) -S(O) 2 -; vii) two units, one from each adjacent X unit, can be taken together to form a substituted or unsubstituted double bond having the formula -CW CW-; wherein each W is hydrogen of a unit having the formula -(L 2 ) j -R 2 , the index j is 0 or 1; R is a carbocyclic or heterocyclic aryl ring; R 1 is a cysteine trap; each R 2 is independently a suitable substituent; and L, L 1 , and L 2 are linking units.