Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade

Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade

The invention relates to substituted polycyclic aryl and heteroaryl pyrazinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions includ...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: South, Michael, Case, Brenda, Dice, Thomas, Fenton, Ricky, Franklin, Gary, Hayes, Michael, Huang, Horng-Chih, Huang, Wei, Jones, Darin, Kusturin, Carrie, Lindmark, Richard, Long, Scott, Neumann, William, Reitz, David, Trujillo, John, Wang, Ching-Cheng, Wood, Rhonda, Zeng, Qingping, Mahoney, Matthew, Parlow, John, Rueppel, Melvin
Format: Patent
Sprache:eng
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The invention relates to substituted polycyclic aryl and heteroaryl pyrazinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.