Novel DNA polymerases having amino acid substitutions and homologs thereof

Thermostable DNA polymerases both in native form and having single amino acid substitutions and optionally N-terminal deletions are disclosed. These polymerases exhibit a substantial improvement of DNA sequencing performance compared to Taq DNA polymerase. The instant DNA polymerases also possess im...

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Bibliographische Detailangaben
Hauptverfasser: Fuller, Carl, Szasz, Joseph
Format: Patent
Sprache:eng
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Zusammenfassung:Thermostable DNA polymerases both in native form and having single amino acid substitutions and optionally N-terminal deletions are disclosed. These polymerases exhibit a substantial improvement of DNA sequencing performance compared to Taq DNA polymerase. The instant DNA polymerases also possess improved salt tolerance.