Rapidly disintegrating comressed tablets comprising biologically active compounds

The invention concerns rapidly disintegrating compressed tablets comprising biologically active compounds, preferably having a lipid-based coating and/or a nominal size of up to about 375 microns. The compressed tablets comprise bulking agents having a surface area to volume ratio greater than about 1.0 cm −1 . The tablets also comprise binders and lubricants and, optionally, fillers, additives and other excipients. The invention also concerns methods for administering biologically active compounds to human or animal patients via the rapidly disintegrating compressed tablets.