Heterocyclic metalloprotease inhibitors

The invention provides compounds of formula 1 as described in the claims, or an optical isomer, diastereomer or enantiomer thereof, or a pharmaceutically-acceptable salt, or biohydrolyzable amide, ester, or imide thereof are useful as inhibitors of metalloproteases. Also disclosed are pharmaceutical...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: De, Biswanath, Pikul, Stanislaw, Cheng, Menyan, Almstead, Neil, Matthews, Randall, Natchus, Michael, Taiwo, Yetunde
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The invention provides compounds of formula 1 as described in the claims, or an optical isomer, diastereomer or enantiomer thereof, or a pharmaceutically-acceptable salt, or biohydrolyzable amide, ester, or imide thereof are useful as inhibitors of metalloproteases. Also disclosed are pharmaceutical compositions and methods of treating diseases, disorders and conditions characterized by metalloprotease activity using these compounds or the pharmaceutical compositions containing them.