(Benzodioxan, benzofuran or benzopyran) derivatives having fundic relaxation properties
The present invention of compounds of formula (I) 1 a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, wherein Alk 1 is C 1-6 alkanediyl optionally substituted with hydroxy, C 1-4 alkyloxy or C 1-4 alkylcarbonyloxy; -Z 1 -Z...
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Format: | Patent |
Sprache: | eng |
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Zusammenfassung: | The present invention of compounds of formula (I)
1
a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, wherein Alk
1
is C
1-6
alkanediyl optionally substituted with hydroxy, C
1-4
alkyloxy or C
1-4
alkylcarbonyloxy; -Z
1
-Z
2
- is a bivalent radical; R
1
, R
2
and R
3
are each independently selected from hydrogen, C
1-6
alkyl, hydroxy, halo and the like; or when R
1
and R
2
are on adjacent carbon atoms, R
1
and R
2
taken together may form a bivalent radical; R
4
is hydrogen or C
1-6
alkyl; A is a bivalent radical of formula -NR
6
-Alk
2
-(b-1), or -Npiperidinyl-(CH
2
)
m
(b-2) wherein m is 0 or 1; R
5
is a radical of formula
2
wherein n is 1 or 2; p
1
is 0, and p
2
is 1 or 2; or p
1
is 1 or 2, and p
2
is 0; X is oxygen, sulfur or NR
9
; Y is oxygen or sulfur; R
7
is hydrogen, C
1-6
alkyl, C
3-6
cycloalkyl, phenyl or phenylmethyl; R
8
is C
1-6
alkyl, C
3-6
cycloalkyl phenyl or phenylmethyl; R
9
is cyano, C
1-6
alkyl, C
3-6
cyclo-alkyl, C
1-6
alkyloxycarbonyl or aminocarbonyl; R
10
is hydrogen or C
1-6
alkyl; and Q is a bivalent radical. Processes for preparing said products, formulations comprising said products and their use as a medicine are disclosed, in particular for treating conditions which are related to impaired fundic relaxation. |
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