Process for preparing terbinafine and HCI salt thereof

Provided are a process for preparing terbinafine or its HCl salt, which comprises: (a) reacting a furan derivative with a base; (b) performing a reductive alkylation of the resulting compound obtained in the step (a) with N-methyl-1-naphthalenemethylamine or its HCl salt; and (c) purifying the resul...

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Bibliographische Detailangaben
Hauptverfasser: Wang, Kyu-Jung, Lee, Tai-Au, Kim, Hong-Bae, Kwon, Kyoung-Chan, Ku, Chang-Hoe
Format: Patent
Sprache:eng
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Zusammenfassung:Provided are a process for preparing terbinafine or its HCl salt, which comprises: (a) reacting a furan derivative with a base; (b) performing a reductive alkylation of the resulting compound obtained in the step (a) with N-methyl-1-naphthalenemethylamine or its HCl salt; and (c) purifying the resulting compound obtained in the step (b).