Heteroaryl derivatives as superior ligands for nociceptin receptor ORL-1
Novel compounds of the formula 1 wherein R is optionally substituted heteroaryl or 2 R 1 is H or C 1 -C 6 alkyl; and R 2 and R 3 are -CH 3 , -OCH 3 or halo; or a pharmaceutically acceptable salt or solvate thereof, pharmaceutical compositions therefore, and the use of said compounds in the treatment...
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| Format: | Patent |
| Sprache: | eng |
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| Zusammenfassung: | Novel compounds of the formula
1
wherein
R is optionally substituted heteroaryl or
2
R
1
is H or C
1
-C
6
alkyl; and
R
2
and R
3
are -CH
3
, -OCH
3
or halo;
or a pharmaceutically acceptable salt or solvate thereof, pharmaceutical compositions therefore, and the use of said compounds in the treatment of pain, anxiety, cough, asthma, depression and alcohol abuse are disclosed. |
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