Human interferon-beta formulations

The invention provides a stable pharmaceutical composition containing biologically active human interferon- (IFN- ), preferably IFN 1 b produced in a bacterial host, dissolved in an aqueous-based solution containing a glycine buffer at a pH of about 2.0 to about 4.0. The invention of also provides s...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: McCaman, Michael, Ottoboni, Susanne, Pungor, Erno
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The invention provides a stable pharmaceutical composition containing biologically active human interferon- (IFN- ), preferably IFN 1 b produced in a bacterial host, dissolved in an aqueous-based solution containing a glycine buffer at a pH of about 2.0 to about 4.0. The invention of also provides stable IFN- lyophilizates prepared from biologically active IFN- , dissolved in an aqueous-based solution containing a glycine buffer at a pH of about 2.0 to about 4.0.