Substituted benzolactam compounds
This invention relates to compounds of the general formula (1): 1 or a pharmaceutically acceptable salt thereof, W, T, Y, X, Q, R 1 , R 2 , and R 3 are defined herein. This invention also relates to compounds of the formula I, depicted above, wherein Y is -NH-; T is (2S,3S)-2-phenylpiperidin-3-yl, w...
Gespeichert in:
1. Verfasser: | |
---|---|
Format: | Patent |
Sprache: | eng |
Online-Zugang: | Volltext bestellen |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | This invention relates to compounds of the general formula (1):
1
or a pharmaceutically acceptable salt thereof, W, T, Y, X, Q, R
1
, R
2
, and R
3
are defined herein. This invention also relates to compounds of the formula I, depicted above, wherein Y is -NH-; T is (2S,3S)-2-phenylpiperidin-3-yl, where the phenyl group of said (2S, 3S)-2-phenylpiperidine-3-yl may optionally be substituted with fluoro; Q is oxygen and is double bonded to the carbon atom to which it is attached, X is methoxy or ethoxy, R
1
is hydrogen, methyl or halo-C
1
-C
2
alkyl, W is methylene, ethylene or vinylene; R
2
and R
3
are independently hydrogen or methyl, or one of R
2
or R
3
may be hydroxy, when W is ethylene, R
2
and R
3
are both methyl, when W is methylene, and R
2
and R
3
are both hydrogen, when W is vinylene. The invention is further directed to methods of treating various CNS and other disorders using said compounds and pharmaceutical compositions thereof. |
---|