Enhanced oral and transcompartmental delivery of therapeutic or diagnostic agents

The invention is directed to pharmaceutical compositions and methods for delivery of a therapeutic or diagnostic agent from one bodily compartment to one or more other bodily compartment by administering one of the following conjugates: a polymer having multiple functional groups at least one of whi...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	Stein, Stanley, Ramanathan, Srinivasan, Leibowitz, Michael, Sinko, Patrick, Minko, Tamara, Williams, Gregory, Zhang, Goubao, Zhang, Xiaoping, Pooyan, Shahrair, Park, Seong, Qiu, Bo, Paranjpe, Pankaj
Format:	Patent
Sprache:	eng
Online-Zugang:	Volltext bestellen
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Beschreibung
Zusammenfassung:	The invention is directed to pharmaceutical compositions and methods for delivery of a therapeutic or diagnostic agent from one bodily compartment to one or more other bodily compartment by administering one of the following conjugates: a polymer having multiple functional groups at least one of which is covalently bound to a therapeutic or diagnostic agent, and at least one cell uptake promoter covalently bound to the therapeutic or diagnostic agent; or a polymer and at least one cell uptake promoter bound thereto; the polymer further comprising multiple functional groups at least one of which is covalently bound a therapeutic or diagnostic agent.