Amide and urea derivatives as 5-HT reuptake inhibitors and as5-HT1B/1D ligands

Amide and urea derivatives of the formula I R 1 -(CH 2 ) n -(Y) q -(Z) r -CO-NH-R 2   (I) in which R 1 , n, Y, q, Z, r and R 2 have the meanings indicated in claim 1, are potent 5-HT 1B/1D antagonists and exhibit 5-HT reuptake-inhibiting actions and are suitable for the treatment and prophylaxis of...

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Hauptverfasser: Van Amsterdam, Christoph, Greiner, Hartmut, Boettcher, Henning, Bartoszyk, Gerd, Harting, Juergen, Matzen, Lisa, Rautenberg, Wilfried
Format: Patent
Sprache:eng
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Zusammenfassung:Amide and urea derivatives of the formula I R 1 -(CH 2 ) n -(Y) q -(Z) r -CO-NH-R 2   (I) in which R 1 , n, Y, q, Z, r and R 2 have the meanings indicated in claim 1, are potent 5-HT 1B/1D antagonists and exhibit 5-HT reuptake-inhibiting actions and are suitable for the treatment and prophylaxis of anxiety states, depressions, schizophrenia, compulsive ideas, tardive dyskinesias, learning disorders, age-dependent memory disorders, for positively affecting obsessive-compulsive behaviour (OCD), and also for the treatment and for the control of the sequelae of cerebral infarcts such as stroke and cerebral ischaemias.