Amide and urea derivatives as 5-HT reuptake inhibitors and as5-HT1B/1D ligands
Amide and urea derivatives of the formula I R 1 -(CH 2 ) n -(Y) q -(Z) r -CO-NH-R 2 (I) in which R 1 , n, Y, q, Z, r and R 2 have the meanings indicated in claim 1, are potent 5-HT 1B/1D antagonists and exhibit 5-HT reuptake-inhibiting actions and are suitable for the treatment and prophylaxis of...
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Format: | Patent |
Sprache: | eng |
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Zusammenfassung: | Amide and urea derivatives of the formula I
R
1
-(CH
2
)
n
-(Y)
q
-(Z)
r
-CO-NH-R
2
(I)
in which R
1
, n, Y, q, Z, r and R
2
have the meanings indicated in claim 1, are potent 5-HT
1B/1D
antagonists and exhibit 5-HT reuptake-inhibiting actions and are suitable for the treatment and prophylaxis of anxiety states, depressions, schizophrenia, compulsive ideas, tardive dyskinesias, learning disorders, age-dependent memory disorders, for positively affecting obsessive-compulsive behaviour (OCD), and also for the treatment and for the control of the sequelae of cerebral infarcts such as stroke and cerebral ischaemias. |
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