Process for the preparation of acetamide derivatives

The invention provides a process for the preparation of diphenylmethylthioacetamide (I) as described in Scheme 4 comprising reacting of the isothiouronium salt or its corresponding base of the formula IV with an acetamide of the formula XCH 2 CONH 2 , wherein X represents a halogen, M represents an...

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Bibliographische Detailangaben
Hauptverfasser: Menashe, Naim, Naddaka, Vladimir, Lexner, Jael, Saeed, Shadi, Kaspi, Joseph, Lerman, Ori
Format: Patent
Sprache:eng
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Zusammenfassung:The invention provides a process for the preparation of diphenylmethylthioacetamide (I) as described in Scheme 4 comprising reacting of the isothiouronium salt or its corresponding base of the formula IV with an acetamide of the formula XCH 2 CONH 2 , wherein X represents a halogen, M represents an alkali metal and A represents an anion, in a protic medium at a temperature of less than 100° C. 1