Arylpiperazines having activity at the serotonin 1A receptor
A method for potentiating the action of a serotonin reuptake inhibitor in increasing the availability of serotonin, norepinephrin and dopamine in the brain, comprising administering to a patient in need of such treatment a serotonin reuptake inhibitor in combination with an effective amount of a com...
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| Format: | Patent |
| Sprache: | eng |
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| Zusammenfassung: | A method for potentiating the action of a serotonin reuptake inhibitor in increasing the availability of serotonin, norepinephrin and dopamine in the brain, comprising administering to a patient in need of such treatment a serotonin reuptake inhibitor in combination with an effective amount of a compound of the formula
1
wherein
Ar′ is a mono or bicyclic aryl or heteroaryl radical substituted with one to three substituents selected from the group consisting of hydrogen, (C
1
-C
6
)alkyl, (C
1
-C
6
)alkoxy, (C
1
-C
6
)alkylthio, (C
2
-C
6
)alkenyl, (C
2
-C
6
)alkynyl, (C
1
-C
6
)alkyl halo, (C
3
-C
8
)cycloalkyl, (C
3
-C
8
)cycloalkenyl or halo;
R
1
is hydrogen, (C
1
-C
6
)alkyl, (C
1
-C
6
)alkoxy, (C
1
-C
6
)alkylthio;
R
2
is phenyl, naphthyl or (C
3
-C
12
)cycloalkyl substituted with one or two substituents selected from the group consisting of hydrogen (C
1
-C
6
)alkyl, (C
1
-C
6
)alkoxy, (C
1
-C
6
)alkylthio, (C
2
-C
6
)alkenyl, (C
2
-C
6
)alkynyl, (C
1
-C
6
)alkyl halo, (C
3
-C
8
)cycloalkyl, (C
3
-C
8
)cycloalkenyl or halo;
R
3
is selected from the group consisting of hydrogen (C
1
-C
6
)alkyl, (C
1
-C
6
)alkoxy, (C
1
-C
6
)alkylthio, (C
2
-C
6
)alkenyl, (C
2
-C
6
)alkynyl, (C
1
-C
6
)alkylhalo, (C
3
-C
8
)cycloalkyl, (C
3
-C
8
)cycloalkenyl or halo;
X is -(C O)-, -CHOH- or -CH
2
-;
or a pharmaceutically acceptable salt, racemate, optical isomer or solvate thereof. |
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