Pyrimidine matrix metalloproteinase inhibitors
Selective MMP-13 inhibitors are pyrimidine derivatives of the formula 1 or a pharmaceutically acceptable salt thereof, wherein: R 2 is hydrogen, halo, hydroxy, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, NO 2 , NR 4 R 5 , CN, or CF 3 ; E is independently O or S; A and B inde...
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| Format: | Patent |
| Sprache: | eng |
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| Zusammenfassung: | Selective MMP-13 inhibitors are pyrimidine derivatives of the formula
1
or a pharmaceutically acceptable salt thereof,
wherein:
R
2
is hydrogen, halo, hydroxy, C
1
-C
6
alkyl, C
1
-C
6
alkoxy, C
2
-C
6
alkenyl, C
2
-C
6
alkynyl, NO
2
, NR
4
R
5
, CN, or CF
3
;
E is independently O or S;
A and B independently are OR
4
or NR
4
R
5
; R
4
and R
5
independently are H, C
1
-C
6
alkyl, C
2
-C
6
alkenyl, C
2
-C
6
alkynyl, (CH
2
)
n
aryl, (CH
2
)
n
cycloalkyl, (CH
2
)n heteroaryl, or R
4
and R
5
when taken together with the nitrogen to which they are attached complete a 3- to 8-membered ring containing carbon atoms and optionally containing a heteroatom selected from O, S, or NH, and optionally substituted or unsubstituted;
n is an integer of from 0 to 6. |
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