Use of membrane cover in prevention of cross-contamination in multiple biological material isolation processing

According to the present invention, there is provided a multiwell device including a multiwell plate having at least one well, wherein each well has an open end portion and a sealing mechanism disposed over each well. The sealing mechanism prevents the loss of contents from each well after the sealing mechanism receives and is penetrated by a material transfer device during a material transfer procedure. Additionally, the present invention provides for a sealing mechanism for being disposed over a plurality of wells of a multiwell plate. The sealing mechanism prevents loss of content from the wells during a material transfer procedure. The present invention also provides for a method of transferring material from the wells of the multiwell device including the steps of puncturing the sealing matrix with the material transfer device and preventing cross-contamination of the content with other wells. Finally, the present invention provides for a method of transferring material from wells of a multiwell device including the steps of puncturing an opening in a sealing matrix, entering the opening with a material transfer device, and preventing cross-contamination of the content with other wells.