Process for stereospecific hydrolysis of piperidinedione derivatives
A process for stereospecifically hydrolysing a mixture of the (+) and (−) isomers of a compound of formula (II), in which R is C 1-6 alkyl; using a carboxyl esterase enzyme, (I) to form a compound of formula (IIIA), and thereafter separating the resulting compound of formula (IIIA) from the remainin...
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| Sprache: | eng |
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| Zusammenfassung: | A process for stereospecifically hydrolysing a mixture of the (+) and (−) isomers of a compound of formula (II), in which R is C
1-6
alkyl; using a carboxyl esterase enzyme, (I) to form a compound of formula (IIIA), and thereafter separating the resulting compound of formula (IIIA) from the remaining (−) isomer of formula (II); or (ii) to form a compound of formula (IIIB) and thereafter separating the resulting compound of formula (IIIB) from the remaining (+) isomer of formula (II). |
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