A Comprehensive Review of Continuous Glucose Monitoring Accuracy during Exercise Periods

[EN] Continuous Glucose Monitoring (CGM) has been a springboard of new diabetes management technologies such as integrated sensor-pump systems, the artificial pancreas, and more recently, smart pens. It also allows patients to make better informed decisions compared to a few measurements per day from a glucometer. However, CGM accuracy is reportedly affected during exercise periods, which can impact the effectiveness of CGM-based treatments. In this review, several studies that used CGM during exercise periods are scrutinized. An extensive literature review of clinical trials including exercise and CGM in type 1 diabetes was conducted. The gathered data were critically analysed, especially the Mean Absolute Relative Difference (MARD), as the main metric of glucose accuracy. Most papers did not provide accuracy metrics that differentiated between exercise and rest (non-exercise) periods, which hindered comparative data analysis. Nevertheless, the statistic results confirmed that CGM during exercise periods is less accurate. This work was supported by the Ministerio de Economía, Industria y Competitividad (MINECO), Grant Number DPI2016-78831-C2-1-R, the Agencia Estatal de Investigación PID2019-107722RB-C21 / AEI /10.13039/501100011033, the European Union (FEDER funds), and the Vicerectorate of Research, Innovation and Technology Transference from the Universitat Politècnica de València (Grant Number PAID-06-18). Muñoz Fabra, E.; Diez, J.; Bondía Company, J.; Laguna Sanz, AJ. (2021). A Comprehensive Review of Continuous Glucose Monitoring Accuracy during Exercise Periods. Sensors. 21(2). https://doi.org/10.3390/s21020479