Computational optical imaging with a photonic lantern

[EN] The thin and flexible nature of optical fibres often makes them the ideal technology to view biological processes in-vivo, but current microendoscopic approaches are limited in spatial resolution. Here, we demonstrate a route to high resolution microendoscopy using a multicore fibre (MCF) with...

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Hauptverfasser: Choudhury, Debaditya, McNicholl, Duncan K, Repetti, Audrey, Gris-Sánchez, Itandehui, Li, Shuhui, Phillips, David B, Whyte, Graeme, Birks, Tim A, Wiaux, Yves, Thomson, Robert R
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Zusammenfassung:[EN] The thin and flexible nature of optical fibres often makes them the ideal technology to view biological processes in-vivo, but current microendoscopic approaches are limited in spatial resolution. Here, we demonstrate a route to high resolution microendoscopy using a multicore fibre (MCF) with an adiabatic multimode-to-single-mode "photonic lantern" transition formed at the distal end by tapering. We show that distinct multimode patterns of light can be projected from the output of the lantern by individually exciting the single-mode MCF cores, and that these patterns are highly stable to fibre movement. This capability is then exploited to demonstrate a form of single-pixel imaging, where a single pixel detector is used to detect the fraction of light transmitted through the object for each multimode pattern. A custom computational imaging algorithm we call SARA-COIL is used to reconstruct the object using only the pre-measured multimode patterns themselves and the detector signals. This work was funded through the "Proteus" Engineering and Physical Sciences Research Council (EPSRC) Interdisciplinary Research Collaboration (IRC) (EP/K03197X/1), by the Science and Technology Facilities Council (STFC) through STFC-CLASP grants ST/K006509/1 and ST/K006460/1, STFC Consortium grants ST/N000625/1 and ST/N000544/1. S.L. acknowledges support from the National Natural Science Foundation of China under Grant no. 61705073. DBP acknowledges support from the Royal Academy of Engineering, and the European Research Council (PhotUntangle, 804626). The authors thank Philip Emanuel for the use of his confocal image of A549 cells and Eckhardt Optics for their image of the USAF 1951 target. The authors sincerely thank the anonymous reviewers of this paper for their detailed and considered feedback which helped us to improve the quality of this paper significantly. Choudhury, D.; Mcnicholl, DK.; Repetti, A.; Gris-Sánchez, I.; Li, S.; Phillips, DB.; Whyte, G... (2020). Computational optical imaging with a photonic lantern. Nature Communications. 11(1):1-9. https://doi.org/10.1038/s41467-020-18818-6 Wood, H. A. C., Harrington, K., Birks, T. A., Knight, J. C. & Stone, J. M. High-resolution air-clad imaging fibers. Opt. Lett. 43, 5311–5314 (2018). Akram, A. R. et al. In situ identification of Gram-negative bacteria in human lungs using a topical fluorescent peptide targeting lipid A. Sci. Transl. Med. 10, eaal0033 (2018). Shin, J., Bosworth, B. T. & Foster, M. A. Compressive