Preparation of benzolactams by Pd(II)-catalyzed carbonylation of N-unprotected arylethylamines

Preparation of benzolactams by Pd(II)-catalyzed carbonylation of N-unprotected arylethylamines

An unprecedented NH2-directed Pd(II)-catalytic carbonylation of quaternary aromatic α -amino esters to yield 6-membered 10 benzolactams has been developed. The reaction shows a strong bias to 6-membered lactams over 5-membered ones. The steric hindrance around the amino group seems to be pivotal for...

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Hauptverfasser: López Barallobre, Blanca, Rodríguez Ramírez, Aleix, Santos, David, Albert Mach, Joan, Ariza Piquer, Xavier, García Gómez, Jordi, Granell Sanvicente, Jaime Ramón
Format: Artikel
Sprache:eng
Schlagworte:
Chemical reactions
Imines
Lactames
Lactams
Organometallic chemistry
Palladium
Pal·ladi (Element químic)
Química organometàl·lica
Reaccions químiques
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Zusammenfassung:An unprecedented NH2-directed Pd(II)-catalytic carbonylation of quaternary aromatic α -amino esters to yield 6-membered 10 benzolactams has been developed. The reaction shows a strong bias to 6-membered lactams over 5-membered ones. The steric hindrance around the amino group seems to be pivotal for the success of the process.
ISSN:1359-7345
DOI:10.1039/C0CC03478A