Shorter androgen receptor polyQ alleles protect against life-threatening COVID-19 disease in European males

Shorter androgen receptor polyQ alleles protect against life-threatening COVID-19 disease in European males

Background: While SARS-CoV-2 similarly infects men and women, COVID-19 outcome is less favorable in men. Variability in COVID-19 severity may be explained by differences in the host genome. Methods: We compared poly-amino acids variability from WES data in severely affected COVID-19 patients versus...

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Hauptverfasser: Baldassarri, Margherita, Picchiotti, Nicola, Fava, Francesca, Fallerini, Chiara, Benetti, Elisa, Daga, Sergio, Valentino, Floriana, Doddato, Gabriella, Furini, Simone, Giliberti, Annarita, Tita, Rossella, Amitrano, Sara, Bruttini, Mirella, Croci, Susanna, Meloni, Ilaria, Pinto, Anna Maria, Iuso, Nicola, Gabbi, Chiara, Sciarra, Francesca, Venneri, Mary Anna, Gori, Marco, Sanarico, Maurizio, Crawley, Francis P, Pagotto, Uberto, Fanelli, Flaminia, Mezzullo, Marco, Dominguez Garrido, Elena, Planas Serra, Laura, Schlüter, Agatha, Colobran, Roger, Soler Palacín, Pere, Lapunzina, Pablo, Tenorio, Jair, Pujol Onofre, Aurora, Castagna, Maria Grazia, Marcelli, Marco, Isidori, Andrea M, Renieri, Alessandra, Frullanti, Elisa, Mari, Francesca, Spanish Covid HGE, GENCOVID Multicenter Study
Format: Artikel
Sprache:eng
Schlagworte:
Androgens
Andrògens
COVID-19
Testosterona
Testosterone
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Zusammenfassung:Background: While SARS-CoV-2 similarly infects men and women, COVID-19 outcome is less favorable in men. Variability in COVID-19 severity may be explained by differences in the host genome. Methods: We compared poly-amino acids variability from WES data in severely affected COVID-19 patients versus SARS-CoV-2 PCR-positive oligo-asymptomatic subjects. Findings: Shorter polyQ alleles (≤22) in the androgen receptor (AR) conferred protection against severe outcome in COVID-19 in the first tested cohort (both males and females) of 638 Italian subjects. The association between long polyQ alleles (≥23) and severe clinical outcome (p = 0.024) was also validated in an independent cohort of Spanish men
DOI:10.1016/j.ebiom.2021.103246