A Straightforward Synthesis of Functionalized cis-Perhydroisoquinolin-1-ones

A Straightforward Synthesis of Functionalized cis-Perhydroisoquinolin-1-ones

Base-catalyzed annulation reactions of 5,6-dihydro-2(1H)-pyridones with Nazarov-type reagents are reported. The effect of the solvent polarity and the concentration of the reagents is studied. The process involves two successive Michael additions and stereoselectively provides functionalized cis-per...

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Hauptverfasser: Arioli, Federica, Pérez Bosch, Maria, Are, Celeste, Molins i Grau, Elies, Bosch Cartes, Joan, Amat Tusón, Mercedes
Format: Artikel
Sprache:eng
Schlagworte:
Chemical tests and reagents
Indicadors (Química)
Indicators and test-papers
Lactames
Lactams
Organic chemistry
Proves i reactius químics
Química orgànica
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Zusammenfassung:Base-catalyzed annulation reactions of 5,6-dihydro-2(1H)-pyridones with Nazarov-type reagents are reported. The effect of the solvent polarity and the concentration of the reagents is studied. The process involves two successive Michael additions and stereoselectively provides functionalized cis-perhydroisoquinolin-1-ones.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules24030557