Genome-wide interaction study of smoking behavior and non-small cell lung cancer risk in Caucasian population

Genome-wide interaction study of smoking behavior and non-small cell lung cancer risk in Caucasian population

Non-small cell lung cancer is the most common type of lung cancer. Both environmental and genetic risk factors contribute to lung carcinogenesis. We conducted a genome-wide interaction analysis between single nucleotide polymorphisms (SNPs) and smoking status (never-versus ever-smokers) in a Europea...

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Hauptverfasser: Li, Yafang, Xiao, Xiangjun, Han, Younghun, Gorlova, Olga, Qian, David, Leighl, Natasha, Johansen, Jakob S, Barnett, Matt, Chen, Chu, Goodman, Gary, Cox, Angela, Taylor, Fiona, Woll, Penella, Wichmann, H.-Erich, Manz, Judith, Muley, Thomas R, Risch, Angela, Rosenberger, Albert, Arnold, Susanne M, Haura, Eric B, Bolca, Ciprian, Holcatova, Ivana, Janout, Vladimir, Kontic, Milica, Lissowska, Jolanta, Mukeriya, Anush, Ognjanovic, Simona, Orlowski, Tadeusz M, Scelo, Ghislaine, Swiatkowska, Beata, Zaridze, David, Bakke, Per, Skaug, Vidar, Zienolddiny, Shanbeh, Duell, Eric J, Butler, Lesley M, Houlston, Richard, Soler Artigas, María, Grankvist, Kjell, Johansson, Mikael, Shepherd, Frances A, Marcus, Michael W, Brunnström, Hans, Manjer, Jonas, Melander, Olle, Muller, David C, Overvad, Kim, Trichopoulou, Antonia, Tumino, Rosario, Liu, Geoffrey, Bojesen, Stig E, Wu, Xifeng, Marchand, Loïc Le, Albanes, Demetrius, Bickeböller, Heike, Aldrich, Melinda C, Bush, William S, Tardón, Adonina, Rennert, Gad, Teare, M. Dawn, Field, John K, Kiemeney, Lambertus A. L. M, Lazarus, Philip, Haugen, Aage, Lam, Stephen, Schabath, Matthew B, Andrew, Angeline S, Bertazzi, Pier Alberto, Pesatori, Angela Cecilia, Christiani, David C, Caporaso, Neil E, Johansson, Mattias, McKay, James D, Brennan, Paul, Hung, Rayjean J, Amos, Christopher I
Format: Artikel
Sprache:eng
Schlagworte:
Carcinogenesis
Carcinogènesi
Càncer de pulmó
Hàbit de fumar
Lung cancer
Smoking
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Zusammenfassung:Non-small cell lung cancer is the most common type of lung cancer. Both environmental and genetic risk factors contribute to lung carcinogenesis. We conducted a genome-wide interaction analysis between single nucleotide polymorphisms (SNPs) and smoking status (never-versus ever-smokers) in a European-descent population. We adopted a two-step analysis strategy in the discovery stage: we first conducted a case-only interaction analysis to assess the relationship between SNPs and smoking behavior using 13 336 non-small cell lung cancer cases. Candidate SNPs with P-value
DOI:10.1093/carcin/bgx113