Relationship between Vancomycin MIC and Virulence Gene Expression in Clonal Complexes of Methicillin-Susceptible Staphylococcus aureus Strains Isolated from Left-sided Endocarditis

Relationship between Vancomycin MIC and Virulence Gene Expression in Clonal Complexes of Methicillin-Susceptible Staphylococcus aureus Strains Isolated from Left-sided Endocarditis

Higher vancomycin MICs have been associated with more complicated courses and higher mortality rates in patients with Staphylococcus aureus bacteremia and infective endocarditis (IE). The aim of this study was to investigate whether the strains belonging to the cohort of 93 patients from a previousl...

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Hauptverfasser: Pericàs, Juan M, Cervera, Carlos, García de la Mària, Cristina, Sharma-Kuinkel, Batu K, Gonzales, Rachelle, Moreno Camacho, Ma. Asunción, Almela, M. (Manel), Falces Salvador, Carles, Quintana, Eduard, Fuster Pelfort, David, Marco Reverté, Francesc, Bayer, Arnold S, Fowler, Vance G, Miró Meda, José M, Hospital Clinic Endocarditis Study Group
Format: Artikel
Sprache:eng
Schlagworte:
Antibiotics
Antibiòtics
Endocarditis
Infeccions per estafilococs
Staphylococcal infections
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Zusammenfassung:Higher vancomycin MICs have been associated with more complicated courses and higher mortality rates in patients with Staphylococcus aureus bacteremia and infective endocarditis (IE). The aim of this study was to investigate whether the strains belonging to the cohort of 93 patients from a previously published study in which patients with strains with vancomycin MICs of ≥1.5 μg/ml presented higher mortality rates and systemic emboli than patients with strains with vancomycin MICs of
ISSN:0066-4804
DOI:10.1128/AAC.01579-19