Concentration and avidity of antibodies to different circumsporozoite epitopes correlate with RTS,S/AS01E malaria vaccine efficacy

Concentration and avidity of antibodies to different circumsporozoite epitopes correlate with RTS,S/AS01E malaria vaccine efficacy

RTS,S/AS01E has been tested in a phase 3 malaria vaccine study with partial efficacy in African children and infants. In a cohort of 1028 subjects from one low (Bagomoyo) and two high (Nanoro, Kintampo) malaria transmission sites, we analysed IgG plasma/serum concentration and avidity to CSP (NANP-r...

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Hauptverfasser: Dobaño, Carlota, 1969, Sanz Ródenas, Héctor, Sorgho, Hermann, Dosoo, David, Mpina, Maximilian, Ubillos, Itziar, Aguilar, Ruth, Ford, Tom, Díez-Padrisa, Núria, Williams, Nana Aba, Ayestaran, Aintzane, Traore, Ousmane, Nhabomba, Augusto J, Jairoce, Chenjerai, Waitumbi, John, Agnandji, Selidji Todagbe, Kariuki, Simon, Abdulla, Salim, Aponte, John J, Mordmüller, Benjamin, Asante, Kwaku Poku, Owusu-Agyei, Seth, Tinto, Halidou, Campo, Joseph J, Moncunill, Gemma, Gyan, Ben, Valim, Clarissa, Daubenberger, Claudia
Format: Artikel
Sprache:eng
Schlagworte:
Africans
Children
Infants
Malaria vaccine
Vacuna de la malària
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Zusammenfassung:RTS,S/AS01E has been tested in a phase 3 malaria vaccine study with partial efficacy in African children and infants. In a cohort of 1028 subjects from one low (Bagomoyo) and two high (Nanoro, Kintampo) malaria transmission sites, we analysed IgG plasma/serum concentration and avidity to CSP (NANP-repeat and C-terminal domains) after a 3-dose vaccination against time to clinical malaria events during 12-months. Here we report that RTS,S/AS01E induces substantial increases in IgG levels from pre- to post-vaccination (p\xE2\x80\x89
ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-019-10195-z