Extending the substrate scope in the hydrogenation of unfunctionalized tetrasubstituted olefins with Ir-P stereogenic aminophosphine-oxazoline catalysts
Air stable and readily available Ir-catalyst precursors modified with MaxPHOX-type ligands have been successfully applied in the challenging asymmetric hydrogenation of tetrasubstituted olefins under mild reaction conditions. Gratifyingly, these catalyst precursors are not only able to efficiently h...
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Sprache: | eng |
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Zusammenfassung: | Air stable and readily available Ir-catalyst precursors modified with MaxPHOX-type ligands have been successfully applied in the challenging asymmetric hydrogenation of tetrasubstituted olefins under mild reaction conditions. Gratifyingly, these catalyst precursors are not only able to efficiently hydrogenate a range of indene derivatives (ee's up to 96%) but also 1,2-dihydro-napthalene derivatives and acyclic olefins (ee's up to 99%), which both constitute the most challenging substrates for this transformation. |
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ISSN: | 1523-7060 |
DOI: | 10.1021/acs.orglett.8b04084 |