Stepwise analysis of MIR9 loci identifies miR-9-5p to be involved in Oestrogen regulated pathways in breast cancer patients

Stepwise analysis of MIR9 loci identifies miR-9-5p to be involved in Oestrogen regulated pathways in breast cancer patients

miR-9 was initially identified as an epigenetically regulated miRNA in tumours, but inconsistent findings have been reported so far. We analysed the expression of miR-9-5p, miR-9-3p, pri-miRs and MIR9 promoters methylation status in 131 breast cancer cases and 12 normal breast tissues (NBTs). The ex...

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Hauptverfasser: Barbano, Raffaela, Pasculli, Barbara, Rendina, Michelina, Fontana, Andrea, Fusilli, Caterina, Copetti, Massimiliano, Castellana, Stefano, Valori, Vanna Maria, Morritti, Maria, Graziano, Paolo, Luigi, Ciuffreda, Coco, Michelina, Picardo, Francesco, Mazza, Tommaso, Evron, Ella, Murgo, Roberto, Maiello, Evaristo, Esteller, Manel, Fazio, Vito Michele, Parrella, Paola
Format: Artikel
Sprache:eng
Schlagworte:
Biochemical markers
Breast cancer
Càncer de mama
Epigenetics
Epigenètica
Estrogen
Estrògens
Marcadors bioquímics
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Zusammenfassung:miR-9 was initially identified as an epigenetically regulated miRNA in tumours, but inconsistent findings have been reported so far. We analysed the expression of miR-9-5p, miR-9-3p, pri-miRs and MIR9 promoters methylation status in 131 breast cancer cases and 12 normal breast tissues (NBTs). The expression of both mature miRs was increased in tumours as compared to NBTs (P 
ISSN:2045-2322
2045-2322
DOI:10.1038/srep45283