A genome wide association study follow-up suggests a possible role of PPARG in systemic esclerosis susceptiblity

Introduction A recent genome-wide association study (GWAS) comprising a French cohort of systemic sclerosis (SSc) reported several non-HLA single-nucleotide polymorphisms (SNPs) showing a nominal association in the discovery phase. We aimed to identify previously overlooked susceptibility variants b...

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Hauptverfasser:	López Isac, Elena, Bossini Castillo, Lara, Simeón Aznar, Carmen Pilar, Egurbide Arberas, María Victoria, Alegre-Sancho, Juan José, Callejas Rubio, José Luis, Román-Ivorra, José Andrés, Freire, Mayka, Beretta, Lorenzo, Santaniello, Alessandro, Airó, Paolo, Lunardi, Claudio, Hunzelmann, Nicolas, Riemestaken, Gabriela, Witte, Torsten, Kreuter, Alexander, Distler, Jörg H.V, Schuerwegh, Annemie J, Vonk, Madelon C, Voskuyl, Alexandre E, Shiels, Paul G, van Laar, Jacob M, Fonseca, Carmen, Denton, Christopher P, Herrick, Ariane L, Worthington, Jane, Assassi, Shervin, Koeleman, Bobby P. C, Mayes, Maureen D, Radstake, Timothy R.D.J, Martín, Javier, Espinosa Garriga, Gerard, Spanish Scleroderma Study Group (SSSG), Narváez García, Francisco Javier
Format:	Artikel
Sprache:	eng
Schlagworte:	Autoimmune diseases Esclerodèrmia Genoma humà Human genome Malalties autoimmunitàries Scleroderma (Disease)
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Zusammenfassung:	Introduction A recent genome-wide association study (GWAS) comprising a French cohort of systemic sclerosis (SSc) reported several non-HLA single-nucleotide polymorphisms (SNPs) showing a nominal association in the discovery phase. We aimed to identify previously overlooked susceptibility variants by using a follow-up strategy. Methods Sixty-six non-HLA SNPs showing a P value
ISSN:	1478-6362
DOI:	10.1186/ar4432