First Enantioselective Synthesis of Tetracyclic Intermediates en route to Madangamine D

First Enantioselective Synthesis of Tetracyclic Intermediates en route to Madangamine D

The enantioselective synthesis of advanced tetracyclic precursors of madangamine D, bearing rings ABCD of this alkaloid, is reported. The saturated 14-membered ring is assembled from functionalized diazatricyclic intermediates 10 following either ring-closing metathesis or macrolactamization strateg...

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Hauptverfasser: Amat Tusón, Mercedes, Ballette, Roberto, Proto, Stefano, Pérez Bosch, Maria, Bosch Cartes, Joan
Format: Artikel
Sprache:eng
Schlagworte:
Alcaloides
Alkaloids
Compostos heterocíclics
Estructura molecular
Heterocyclic compounds
Molecular structure
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Beschreibung
Zusammenfassung:The enantioselective synthesis of advanced tetracyclic precursors of madangamine D, bearing rings ABCD of this alkaloid, is reported. The saturated 14-membered ring is assembled from functionalized diazatricyclic intermediates 10 following either ring-closing metathesis or macrolactamization strategies.
ISSN:1359-7345
DOI:10.1039/C3CC41104D