Application of Mentofin® in broilers with clinical infectious bursal disease to reduce Escherichia coli related problems after vaccination against Newcastle disease

In this study Mentofin® was used in commercial broiler chickens naturally exposed to infectious bursal disease virus (IBDV) and administered live Newcastle disease virus (NDV) vaccine to evaluate the ability of Mentofin® to reduce Escherichia coli-related respiratory lesions, immunomodulate Newcastle disease (ND) vaccine response, change pharyngeal aerobic bacterial counts, and have certain impacts on specific production parameters. Mentofin® was added to the drinking water (100 ml/500 l water) of broiler chickens aged between 3 and 5 days. ND and IBD vaccinations were administered via drinking water to 15-day-old chickens. NDV vaccination was given again when the chickens were 20 days old. No difference was found between the control and Mentofin® groups regarding oropharyngeal aerobic bacterial counts. Acute IBD was diagnosed in both groups because the antibody levels were unprotective and varied widely. The mean NDV-hemagglutination inhibition antibody titers obtained with NDV vaccination in both groups were above the protective level, and the titers were considered uniform. The data showed that Mentofin® was able to reduce the lesions caused by E. coli after NDV vaccination. Mentofin® also reduced the rate of mortality in broilers with IBD interaction to the live NDV. In conclusion, Mentofin® reduced both the occurrence of E. coli-related lesions and the mortality rate usually observed after administering live NDV to broilers with clinical IBD. Bu çalışmada, saha kaynaklı Infeksiyöz Bursal Hastalık Virusu ve canlı NDV aşısına maruz kalan ticari broiler piliçlerde Mentofin® kullanılarak, Mentofinin Escherichia coli'ye bağlı solunumla ilgili lezyonları indirgeyebilmesi , ND aşılaması bağışıklık yanıtı, faringeal aerobik bakteri miktarı değişimi ve spesifik üretim parametreleri üzerindeki belirli etkileri değerlendirildi. Mentofin® 100 ml / 500 l suya doze edilerek 3-5 yaştaki günler arası içme suyuna uygulandı. Onbeş günlük yaştaki civcivlere içme suyu yoluyla ND ve IBD aşılamaları yapıldı. ND aşısı 20. günde tekrarlandı. Mentofin® ve kontrol grupları arasında orofaringeal aerobik bakteri miktarı bakımından farklılık bulunamadı. Antikor yanıtındaki geniş ölçekli değişkenlik ve korumasızlıktan dolayı her iki grupta da akut IBD teşhis edildi. NDV aşılamasından sağlanan ortalama NDV-Hemaglütinasyon İnhibisyon-antikor titreleri 2 grupta da koruyucu düzeyin üzerindeydi ve titreler uniform bulundu. Veriler Mentofin®'in NDV aşılaması sonrası E. coli'ye bağlı lez