Unable To Protect Gentamicin-Induced Nephrotoxicity With Allopurinol In Rats

In this study, it is purposed to investigate the protective effects of allopurinol, a xanthine oxidase inhibitor, against gentamicin -induced nephrotoxicosis. The levels of serum urea, creatinine and plasma MDA were significantly higher and GSH-Px, SOD activities were lower in gentamicin administrated group than the control. The levels of serum urea, creatinine and plasma MDA were significantly higher and GSH-Px, SOD and CAT activities were significantly lower in gentamicin + allopurinol administrated group than the control. Plasma MDA was significantly lower and GSH-Px, SOD activities were higher in gentamicin induced group than gentamicin + allopurinol induced group. In conclusion, results demonstrate that allopurinol, a xanthine oxidase inhibitor, does not prevent the formation of gentamicin induced nephrotoxicosis.