Synthesis, reactions, and antiarrhythmic activities of some novel pyrimidines and pyridines fused with thiophene moiety
We report herein the synthesis and antiarrhythmic activities of some newly synthesized heterocyclic theino[2,3-c]pyrimidine and theino[2,3-c]pyridine derivatives fused with thiophene moiety. Initially the acute toxicity of the compounds was assayed via the determination of their LD50 . The antiarrhy...
Gespeichert in:
Veröffentlicht in: | Turkish journal of chemistry 2009, Vol.33 (3), p.421-432 |
---|---|
Hauptverfasser: | , , , |
Format: | Artikel |
Sprache: | eng |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | We report herein the synthesis and antiarrhythmic activities of some newly synthesized heterocyclic
theino[2,3-c]pyrimidine and theino[2,3-c]pyridine derivatives fused with thiophene moiety. Initially the acute
toxicity of the compounds was assayed via the determination of their LD50 . The antiarrhythmic activities
for the compounds were determined and all the tested compounds were found more potent than Procaine $amide^{\circledR}$
and $Lidocaine^{\circledR}$ as positive antiarrhythmic controls. |
---|---|
ISSN: | 1303-6130 1300-0527 1303-6130 |
DOI: | 10.3906/kim-0811-16 |