Synthesis, reactions, and antiarrhythmic activities of some novel pyrimidines and pyridines fused with thiophene moiety

We report herein the synthesis and antiarrhythmic activities of some newly synthesized heterocyclic theino[2,3-c]pyrimidine and theino[2,3-c]pyridine derivatives fused with thiophene moiety. Initially the acute toxicity of the compounds was assayed via the determination of their LD50 . The antiarrhy...

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Veröffentlicht in:Turkish journal of chemistry 2009, Vol.33 (3), p.421-432
Hauptverfasser: AMR, ABD EL-GALIL E., ABDEL-HAFEZ, NAGLAA A., MOHAMED, SALWA F., ABDALLA, MOHAMED M.
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Sprache:eng
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Zusammenfassung:We report herein the synthesis and antiarrhythmic activities of some newly synthesized heterocyclic theino[2,3-c]pyrimidine and theino[2,3-c]pyridine derivatives fused with thiophene moiety. Initially the acute toxicity of the compounds was assayed via the determination of their LD50 . The antiarrhythmic activities for the compounds were determined and all the tested compounds were found more potent than Procaine $amide^{\circledR}$ and $Lidocaine^{\circledR}$ as positive antiarrhythmic controls.
ISSN:1303-6130
1300-0527
1303-6130
DOI:10.3906/kim-0811-16