Risk of Cognitive Impairment in Patients With Parkinson's Disease With Visual Hallucinations and Subjective Cognitive Complaints

Visual hallucinations (VH) and subjective cognitive complaints (SCC) are associated with cognitive impairment (CI) in Parkinson's disease. Our aims were to determine the association between VH and SCC and the risk of CI development in a cohort of patients with Parkinson's disease and norma...

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Hauptverfasser: Santos García, Diego, de Deus Fonticoba, Teresa, Bartolomé, Carlos C, Feal Painceiras, Maria J, Paz González, Jose M, Martinez Miró, Cristina, Jesús, Silvia, Aguilar, Miguel, Pastor, Pau, Planellas, Lluis, Cosgaya, Marina, Garcia Caldentey, Juan, Caballol, Nuria, Legarda, Ines, Hernández-Vara, Jorge, Cabo-Lopez, Iria, Lopez Manzanares, Lydia, Gonzalez Aramburu, Isabel, Ávila Rivera, Maria A, Gomez Mayordomo, Victor, Nogueira, Victor, Puente, Victor, Dotor García-Soto, Julio, Borrué, Carmen, Solano Vila, Berta, Álvarez Sauco, Maria, Vela, Lydia, Escalante, Sonia, Cubo, Esther, Carrillo Padilla, Francisco, Martinez Castrillo, Juan C, Sanchez Alonso, Pilar, Alonso Losada, M.G, Lopez Ariztegui, Nuria, Gastón, Itziar, Kulisevsky, Jaime, Blázquez Estrada, Marta, Seijo, Manuel, Ruiz Martínez, Javier, Valero, Caridad, Kurtis, Monica, Fàbregues-Boixar i Nebot, Oriol de, Gonzalez Ardura, Jessica, Alonso Redondo, Ruben, Ordás, Carlos, Lopez Diaz L., Luis M, McAfee, Darrian, Martinez-Martin, Pablo, Mir, Pablo, Coppadis Study Group, None, Universitat Autònoma de Barcelona
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Zusammenfassung:Visual hallucinations (VH) and subjective cognitive complaints (SCC) are associated with cognitive impairment (CI) in Parkinson's disease. Our aims were to determine the association between VH and SCC and the risk of CI development in a cohort of patients with Parkinson's disease and normal cognition (PD-NC). Methods Patients with PD-NC (total score of >80 on the Parkinson's Disease Cognitive Rating Scale [PD-CRS]) recruited from the Spanish COPPADIS cohort from January 2016 to November 2017 were followed up after 2 years. Subjects with a score of ≥1 on domain 5 and item 13 of the Non-Motor Symptoms Scale at baseline (V0) were considered as "with SCC" and "with VH," respectively. CI at the 2-year follow-up (plus or minus 1 month) (V2) was defined as a PD-CRS total score of