Glioblastoma cell fate is differentially regulated by the microenvironments of the tumor bulk and infiltrative margin

This work was funded by Cancer Research UK (C55501/A21203, C555011/A22572, C25858/A28592), the Cancer Research UK City of London Centre Award (C7893/A26233), the Radiation Research Unit at the Cancer Research UK City of London Centre Award (C7893/A28990), the NIHR Biomedical Research Centre (BRC507/CN/SP/101330), the Oli Hilsdon Foundation through The Brain Tumour Charity (GN-000595), the MCIN (PID2020-115439GB-I00), and the Fundació la Marató de TV3 (772/C/2019). We thank A. Berns for Cdkn2a−/− mice, M. Aguet for Ifnar1−/− and Ifnar1−/−;Ifngr1−/− mice, P. Salomoni and S. Pollard for constructs, B. Antolin-Fontes for cloning, G. Rodriguez-Esteban for bioinformatics, M. Pathania for technical advice, A. Flanagan for histopathological advice, J. Manji for microscopy, and Y. Guo, G. Morrow, and B. Wilbourn for FACS. Graphical abstract and Figure 2L were created with BioRender.com. Conceptualization, S.P.; methodology, C.G.D. M.C. L.J.B. H.H. S.A.Q. Y.Y. and S.P.; software, E.M. H.H. S.P.C. and Y.Y.; validation, C.G.D. A.P. L.J.B. L.C. and M.C.; formal analysis, C.G.D. E.M. A.P. L.J.B. W.T. G.B. F.G-C, S.P.C. L.C. and F.R.; investigation, C.G.D. M.C. A.P. L.J.B. F.G-C. L.C. and S.R.; resources, H.H. S.A.Q. Y.Y. and S.P.; data curation, E.M. W.T. and G.B.; writing - original draft, C.G.D. M.C. E.M. and S.P.; writing - review & editing, L.J.B. A.P. M.C. S.M. and S.P.; visualization, C.G.D. E.M. A.P. S.P.C. G.B. and S.P.; supervision, H.H. S.A.Q. Y.Y. S.M. and S.P.; project administration, S.P.; funding acquisition, H.H. S.Q. Y.Y. and S.P. H.H. is a co-founder of and equity holder in Omniscope, a scientific advisory board member of MiRXES, and a consultant to Moderna. We support inclusive, diverse, and equitable conduct of research. This work was funded by Cancer Research UK (C55501 / A21203, C555011/A22572, C25858/A28592), the Cancer Research UK City of London Centre Award (C7893 / A26233), the Radiation Research Unit at the Cancer Research UK City of London Centre Award (C7893/A28990), the NIHR Biomedical Research Centre (BRC507 /CN/SP/101330), the Oli Hilsdon Foundation through The Brain Tumour Charity (GN-000595), the MCIN (PID2020-115439GB-I00), and the Fundació la Marató de TV3 (772/C/2019). We thank A. Berns for Cdkn2a −/− mice, M. Aguet for Ifnar1 −/− and Ifnar1 −/− ;Ifngr1 −/− mice, P. Salomoni and S. Pollard for constructs, B. Antolin-Fontes for cloning, G. Rodriguez-Esteban for bioinformatics, M. Pathania for technical advice, A. Flanagan for histopath