Down syndrome as risk factor for respiratory syncytial virus hospitalization : A prospective multicenter epidemiological study

Respiratory syncytial virus (RSV) infection in childhood, particularly in premature infants, is associated with significant morbidity and mortality. To compare the hospitalization rates due to RSV infection and severity of disease between infants with and without Down syndrome (DS) born at term and...

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Hauptverfasser:	Sánchez Luna, Manuel, Medrano, Constancio, Lirio, Julián, Suazo, José Antonio Hurtado, Peña, Manuela, López, Eduardo Narbona, Fernández, José Uberos, Perales, Antonio Bonillo, Delgado, Javier Díes, Ortega Montes, María Ángeles, de la Cruz Moreno, Jesús, Ortiz Tardío, Joaquín, Esteban, María Victoria, Millán, Leticia, Salido Peracaula, Carlos, Martínez Pajares, José David, Lubián López, Simón Pedro, Ariza Aranda, Salvador, Faci Ventura, María Purificación, Valle Guillén, Sofía, Bueno Lozano, Olga, Rite Gracia, Segundo, Bejarano Ramírez, Natalia, Fresneda Machado, María Carmen, Martínez Gutiérrez, Andrés, Rellán Rodríguez, Sara, Marcos Temprano, Marianela, Ortega Vicente, Elena, Centeno Malfaz, Fernando, San Feliciano Martín, Laura, Remesal Escalero, Ana, Closa-Monasterolo, Ricardo, Franch Salvadó, Silvia, Anquela Sanz, Israel Fernando, Bosch Castells, Joaquim, Trujillo Fagundo, Alberto, Ametller Malfaz, Emma, Sánchez Fernández, Mario José, Solé Mir, Eduard, Coroleu Lletget, Wifredo, Arroyo Carrera, Ignacio, Taboada Perianes, María, Couce Pico, María Luz, Fernández Seara, María José, Ruiz del Prado, María Yolanda, Maderuelo, Elena, Zeballos, Susana, Leal Orozco, Ana, Ruíz Serrano, Cristina, Omeñaca, Félix, Escribano Palomino, Esperanza, García Guereta, Luis, Bosch Jiménez, Vicente, Gutiérrez Sánchez, José Diego, Cidrás Pidre, Manuel, Viguria Sánchez, Natividad, Goñi Orayen, Concepción, Pérez Legorburu, Alberto, Palao Ortuño, María José, Giner Crespo, Maribel, Izquierdo Macián, María Isabel, Gómez Zafra, Rafael, Mayordomo Colunga, Juan, Rosón Varas, María, Mora Matilla, María, Oulego-Erróz, Ignacio, Prada Pereira, María Teresa, Arias Consuegra, Miguel Ángel, Castells Vilella, Laura, Mairal Cazcarra, Jesús Antonio, Yévenes Ruiz, Sílvia, Sáez Díez, Isabel, García Reymundo, Mercedes, Piñán López, Esther, Fernández Sarabia, Javier, Hernández Cáceres, Sofía, López Lois, María Gloria, Olivas, Cristina, Rivero Martín, María José, de las Heras Ibarra, Susana, Cuadrado, Mercedes, Ramos Amador, Jose Tomás, Guillén Martín, Sara, Cañete Díaz, Alfonso, Sopeña Corvino, Julia, González-Valcárcel Sánchez, Francisco Javier, Cambra Sirera, Jose, Pérez García, Begoña, Jiménez Candel, Maria Isabel, Cueto Calvo, Elisa, Guardia, Leonor, Lirio Casero, Julián, Ginovart Galiana, Gemma, López Bernal, Ester, Sánchez de León, Lorenzo, Ferrandez, María Jesús, Quiles, Jose Luís, Rimblas, María, Larrosa Capaces, Susana, Universitat Autònoma de Barcelona
Format:	Artikel
Sprache:	eng
Schlagworte:	Down syndrome Hospitalization Palivizumab Prospective birth cohort study Respiratory syncytial virus
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Zusammenfassung:	Respiratory syncytial virus (RSV) infection in childhood, particularly in premature infants, is associated with significant morbidity and mortality. To compare the hospitalization rates due to RSV infection and severity of disease between infants with and without Down syndrome (DS) born at term and without other associated risk factors for severe RSV infection. In a prospective multicentre epidemiological study, 93 infants were included in the DS cohort and 68 matched by sex and data of birth (±1 week) and were followed up to 1 year of age and during a complete RSV season. The hospitalization rate for all acute respiratory infection was significantly higher in the DS cohort than in the non-DS cohort (44.1% vs 7.7%, P