MyD88 and TLR4 Expression in Epithelial Ovarian Cancer

MyD88 and TLR4 Expression in Epithelial Ovarian Cancer

To evaluate myeloid differentiation primary response gene 88 (MyD88) and Toll-like receptor 4 (TLR4) expression in relation to clinical features of epithelial ovarian cancer, histologic subtypes, and overall survival. We conducted centralized immunohistochemical staining, semi-quantitative scoring,...

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Hauptverfasser: Block, Matthew S, Rambau, Peter F, Sinn, Peter, Sieh, Weiva, Rothstein, Joseph H, Ramon y Cajal, Teresa, Oszurek, Oleg, Orsulic, Sandra, Ness, Roberta B, Nelson, Gregg, Modugno, Francesmary, Menkiszak, Janusz, Lubinski, Jan, Longacre, Teri A, Kalli, Kimberly R, Johnatty, Sharon E, Intermaggio, Maria P, Herpel, Esther, Hartkopf, Andreas D, Harnett, Paul R, Ghatage, Prafull, García-Bueno, José M, Brucker, Sara Y, Bowtell, David D, Green, A, Pandeya, N, Vanden Bergh, T, Jones, M, Sullivan, H, Brown, S, Martin, K, White, J, Giles, D, Alsop, K, Shirley, H, Ball, Collen, Tran, Hoa, Brooks, Julia, Rutovitz, J, Clingan, P, Shannon, J, Bonaventura, T, Stewart, J, Baron-Hay, Sally E, Nevell, David F, Valmadre, Susan, Camaris, Catherine, Crouch, Roger, Marsden, Donald E, Carter, Jodi, Dalrymple, Christopher J, Houghton, Roger, Russell, Prudence Anne, Links, Matthew, Brand, Alison Hilary, Wain, Gerard, Ward, Bruce Gordon, Cummings, M, Perrin, L, Nicklin, J, Oehler, M.K, Hall, C, Pittman, K, Henderson, D, Miller, J, Pierdes, J, Brown, B, Rome, R, Hyde, S, Robbie, M, Jobling, T, Sumithran, E, Simpson, I, Phillips, K, Fox, S, Johnson, D, Lade, S, Loughrey, M, O'Callaghan, N, Billson, V, Pyman, J, Bell, R, Blum, R, Ganju, V, Hammond, I, McCartney, A, Whiteman, D, Zeps, N, Whittemore, Alice S, Menon, Usha, Koziak, Jennifer M, Kommoss, Stefan, Kjaer, Susanne K, Høgdall, Estrid, Gilks, Blake, García, María José, Fasching, Peter A, Candido dos Reis, Francisco J, Ramus, Susan J, Goode, Ellen L
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Zusammenfassung:To evaluate myeloid differentiation primary response gene 88 (MyD88) and Toll-like receptor 4 (TLR4) expression in relation to clinical features of epithelial ovarian cancer, histologic subtypes, and overall survival. We conducted centralized immunohistochemical staining, semi-quantitative scoring, and survival analysis in 5263 patients participating in the Ovarian Tumor Tissue Analysis consortium. Patients were diagnosed between January 1, 1978, and December 31, 2014, including 2865 high-grade serous ovarian carcinomas (HGSOCs), with more than 12,000 person-years of follow-up time. Tissue microarrays were stained for MyD88 and TLR4, and staining intensity was classified using a 2-tiered system for each marker (weak vs strong). Expression of MyD88 and TLR4 was similar in all histotypes except clear cell ovarian cancer, which showed reduced expression compared with other histotypes (P