A Clinical-Genetic Score for Predicting Weight Loss after Bariatric Surgery : The OBEGEN Study

A Clinical-Genetic Score for Predicting Weight Loss after Bariatric Surgery : The OBEGEN Study

Around 30% of the patients that undergo bariatric surgery (BS) do not reach an appropriate weight loss. The OBEGEN study aimed to assess the added value of genetic testing to clinical variables in predicting weight loss after BS. A multicenter, retrospective, longitudinal, and observational study in...

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Hauptverfasser: Ciudin, Andreea, Fidilio, Enzamaría, Gutiérrez-Carrasquilla, Liliana, Caixàs i Pedragós, Assumpta, Vilarrasa, Nuria, Pellitero, Silvia, Simó-Servat, Andreu, Vilallonga, Ramon, García Ruiz de Gordejuela, Amador, de la Fuente, Maricruz, Luna, Alexis, Sánchez, Enric, Rigla Cros, Mercedes, Hernández, Cristina, Salas, Eduardo, Simó Canonge, Rafael, Lecube, Albert, Universitat Autònoma de Barcelona
Format: Artikel
Sprache:eng
Schlagworte:
Bariatric surgery
Genetics
Obesity
Polygenic risk
Weight loss
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Zusammenfassung:Around 30% of the patients that undergo bariatric surgery (BS) do not reach an appropriate weight loss. The OBEGEN study aimed to assess the added value of genetic testing to clinical variables in predicting weight loss after BS. A multicenter, retrospective, longitudinal, and observational study including 416 patients who underwent BS was conducted (Clinical.Trials.gov- NCT02405949). 50 single nucleotide polymorphisms (SNPs) from 39 genes were examined. Receiver Operating Characteristic (ROC) curve analysis were used to calculate sensitivity and specificity. Satisfactory response to BS was defined as at nadir excess weight loss