Pulse Wave Amplitude Drops Index : A Biomarker of Cardiovascular Risk in Obstructive Sleep Apnea

It is currently unclear which patients with obstructive sleep apnea (OSA) are at increased cardiovascular risk. To investigate the value of pulse wave amplitude drops (PWADs), reflecting sympathetic activations and vasoreactivity, as a biomarker of cardiovascular risk in OSA. PWADs were derived from...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	Solelhac, Geoffroy, Sánchez-de-la-Torre, Manuel, Blanchard, Margaux, Berger, Mathieu, Hirotsu, Camila, Imler, Théo, Sánchez-de-la-Torre, Alicia, Haba-Rubio, José, Marchi, Nicola Andrea, Bayon, Virginie, Bailly, Sébastien, Goupil, François, Waeber, Adrien, Heiniger, Grégory, Pigeanne, Thierry, Gracia-Lavedan, Esther, Zapater, Andrea, Abad Capa, Jorge, Ordax, Estrella, Masdeu, María José, Cabriada-Nuño, Valentín, Egea, Carlos J, Van Den Broecke, Sandra, Vollenweider, Peter, Marques-Vidal, Pedro, Vaucher, Julien, Bernardi, Giulio, Betta, Monica, Siclari, Francesca, Barbé, Ferran, Gagnadoux, Frédéric, Heinzer, Raphael, Universitat Autònoma de Barcelona
Format:	Artikel
Sprache:	eng
Schlagworte:	Cardiovascular risk Pulse oximeter Pulse wave amplitude PWAD Sleep apnea
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	It is currently unclear which patients with obstructive sleep apnea (OSA) are at increased cardiovascular risk. To investigate the value of pulse wave amplitude drops (PWADs), reflecting sympathetic activations and vasoreactivity, as a biomarker of cardiovascular risk in OSA. PWADs were derived from pulse oximetry-based photoplethysmography signals in three prospective cohorts: HypnoLaus (N = 1,941), the Pays-de-la-Loire Sleep Cohort (PLSC; N = 6,367), and "Impact of Sleep Apnea syndrome in the evolution of Acute Coronary syndrome. Effect of intervention with CPAP" (ISAACC) (N = 692). The PWAD index was the number of PWADs (>30%) per hour during sleep. All participants were divided into subgroups according to the presence or absence of OSA (defined as ⩾15 or more events per hour or