MYC Inhibition Halts Metastatic Breast Cancer Progression by Blocking Growth, Invasion, and Seeding

MYC Inhibition Halts Metastatic Breast Cancer Progression by Blocking Growth, Invasion, and Seeding

While MYC role in metastasis has been long controversial, this manuscript demonstrates that MYC inhibition by either transgenic expression or pharmacologic use of the recombinantly produced Omomyc miniprotein exerts antitumor and antimetastatic activity in breast cancer models in vitro and in vivo,...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Massó Vallés, Daniel, Beaulieu, Marie-Eve, Jauset González, Toni, Giuntini, Fabio, Zacarías-Fluck, Mariano F, Foradada Felip, Laia, Martínez-Martín, Sandra, Serrano, Erika, Martín-Fernández, Génesis, Casacuberta-Serra, Sílvia, Castillo Cano, Virginia, Kaur, Jastrinjan, López-Estévez, Sergio, Morcillo, Miguel Ángel, Alzrigat, Mohammad, Mahmoud, Loay, Luque-García, Antonio, Escorihuela, Marta, Guzman, Marta, Arribas, Joaquín V, Serra, Violeta, Larsson, Lars-Gunnar, Whitfield, Jonathan R, Soucek, Laura
Format: Artikel
Sprache:eng
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:While MYC role in metastasis has been long controversial, this manuscript demonstrates that MYC inhibition by either transgenic expression or pharmacologic use of the recombinantly produced Omomyc miniprotein exerts antitumor and antimetastatic activity in breast cancer models in vitro and in vivo, suggesting its clinical applicability.