Shorter androgen receptor polyQ alleles protect against life-threatening COVID-19 disease in European males

Shorter androgen receptor polyQ alleles protect against life-threatening COVID-19 disease in European males

While SARS-CoV-2 similarly infects men and women, COVID-19 outcome is less favorable in men. Variability in COVID-19 severity may be explained by differences in the host genome. We compared poly-amino acids variability from WES data in severely affected COVID-19 patients versus SARS-CoV-2 PCR-positi...

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Hauptverfasser: Baldassarri, Margherita, Picchiotti, Nicola, Fava, Francesca, Fallerini, Chiara, Benetti, Elisa, Daga, Sergio, Valentino, Floriana, Doddato, Gabriella, Furini, Simone, Giliberti, Annarita, Tita, Rossella, Amitrano, Sara, Bruttini, Mirella, Croci, Susanna, Meloni, Ilaria, Pinto, Anna Maria, Iuso, Nicola, Gabbi, Chiara, Sciarra, Francesca, Venneri, Mary Anna, Gori, Marco, Sanarico, Maurizio, Crawley, Francis P, Pagotto, Uberto, Fanelli, Flaminia, Mezzullo, Marco, Domínguez-Garrido, Elena, Planas-Serra, Laura, Schlüter, Agatha, Colobrán Oriol, Roger, Soler-Palacín, Pere, Lapunzina, Pablo, Tenorio, Jair, Pujol, Aurora, Castagna, Maria Grazia, Marcelli, Marco, Isidori, Andrea M, Renieri, Alessandra, Frullanti, Elisa, Mari, Francesca, Universitat Autònoma de Barcelona
Format: Artikel
Sprache:eng
Schlagworte:
Androgen receptor gene
COVID-19
LASSO logistic regression
Testosterone
Viral infection and host genome
WES
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Zusammenfassung:While SARS-CoV-2 similarly infects men and women, COVID-19 outcome is less favorable in men. Variability in COVID-19 severity may be explained by differences in the host genome. We compared poly-amino acids variability from WES data in severely affected COVID-19 patients versus SARS-CoV-2 PCR-positive oligo-asymptomatic subjects. Shorter polyQ alleles (≤22) in the androgen receptor (AR) conferred protection against severe outcome in COVID-19 in the first tested cohort (both males and females) of 638 Italian subjects. The association between long polyQ alleles (≥23) and severe clinical outcome (p = 0.024) was also validated in an independent cohort of Spanish men