IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper

Currently, testing for immunoglobulin E (IgE) sensitization is the cornerstone of diagnostic evaluation in suspected allergic conditions. This review provides a thorough and updated critical appraisal of the most frequently used diagnostic tests, both in vivo and in vitro. It discusses skin tests, c...

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Bibliographische Detailangaben
Hauptverfasser:	Ansotegui Zubeldia, Ignacio Javier, Melioli, Giovanni, Canonica, G. Walter, Caraballo, Luis, Villa, Elisa, Ebisawa, Motohiro, Passalacqua, Giovanni, Savi, Eleonora, Ebo, Didier, Gómez, R. Maximiliano, Luengo Sánchez, Olga, Oppenheimer, John J, Jensen-Jarolim, Erika, Fischer, David A, Haahtela, Tari, Antila, Martti, Bousquet, Jean, Cardona, Victoria, Chiang, Wen Chin, Demoly, Pascal, DuBuske, Lawrence M, Ferrer Puga, Marta, Gerth van Wijk, Roy, González Díaz, Sandra Nora, Gonzalez-Estrada, Alexei, Jares, Edgardo, Kalpaklioğlu, Ayse Füsun, Kase Tanno, Luciana, Kowalski, Marek L, Ledford, Dennis K, Monge Ortega, Olga Patricia, Morais Almeida, Mário, Pfaar, Oliver, Poulsen, Lars K, Pawankar, Ruby, Renz, Harald E, Romano, Antonino G, Rosário Filho, Nelson A, Rosenwasser, Lanny, Sánchez Borges, Mario A, Scala, Enrico, Senna, Gian-Enrico, Sisul, Juan Carlos, Tang, Mimi L. K, Thong, Bernard Yu-Hor, Valenta, Rudolf, Wood, Robert A, Zuberbier, Torsten, Universitat Autònoma de Barcelona
Format:	Artikel
Sprache:	eng
Schlagworte:	AAAAI, American Academy of Allergy Asthma and Immunology ABA, Allergen Bead Array ACAAI, American College of Allergy Asthma and Immunology AEC, Allergen Exposure Chambers AIT, allergen immunotherapy Allergy Anti-IgE, Antibody against IgE AP, Alkaline Phosphatase AU/mL, Allergenic Units milliLiter BAT, Basophil Activation Test BAU/mL, Biologic Allergenic Units milliLiter CaFE, Calibrated Fluorescence Enhancement CBA, Cytometric Bead Array CCD, Cross-reactive Carbohydrate Determinants CDER, Center for Drug Evaluation and Research (USA) CL, Chemiluminescence DBPCFC, Double-Blind Placebo-Controlled Food Challenge Diagnostic strategies EAACI, European Academy of Allergy and Immunology EIA, Enzyme Immune Assay ELISA, Enzyme Linked Immuno Sorbent Analysis EMEA, European MEdicine Agencies ENPP-3, EctoNucleotide Pyrophosphatase/Phosphodiesterase 3 FACS, Fluorescence-Activated Cell Sorting FcεRI, High affinity IgE receptor FDA, Food and Drug Administration (U.S. Department of Health and Human Services) FEIA, Fluorescent Enzyme Immunoassays H1, Histamine 1 receptor H2, Histamine 2 receptor HPO, Horseradish Peroxidase IDT, Intradermal Test IgE IgE, immunoglobulin E In vitro tests ISAC, Immuno-Solid phase Allergen Chip IUIS, International Union of Immunological Societies IVD, in vitro diagnostic tool Ku/l, kilo Units of Allergen/Liter for allergen-specific IgE antibody assays LAMP-3, Lysosomal-Associated Membrane Protein Mab, Monoclonal Antibody MBAD, Molecule Based Allergy Diagnostics MRGPRX2, Mas-related G protein receptor 2 NIH, National Institutes of Health (USA) NMBAs, NeuroMuscular Blocking Agents NPA, Negative Percent Agreement NSAIDs, Non-Steroidal Anti-Inflammatory Drugs Pnpp, p -Nitrophenylphosphate PPA, Positive Percent Agreement PPT, Prick-Prick Test RAST, Radio Allergo Sorbent Test SCAR, severe cutaneous adverse drug reactions Sige, specific IgE Skin tests SPT, Skin prick test W/v, weight /volume
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Beschreibung
Zusammenfassung:	Currently, testing for immunoglobulin E (IgE) sensitization is the cornerstone of diagnostic evaluation in suspected allergic conditions. This review provides a thorough and updated critical appraisal of the most frequently used diagnostic tests, both in vivo and in vitro. It discusses skin tests, challenges, and serological and cellular in vitro tests, and provides an overview of indications, advantages and disadvantages of each in conditions such as respiratory, food, venom, drug, and occupational allergy. Skin prick testing remains the first line approach in most instances; the added value of serum specific IgE to whole allergen extracts or components, as well as the role of basophil activation tests, is evaluated. Unproven, non-validated, diagnostic tests are also discussed. Throughout the review, the reader must bear in mind the relevance of differentiating between sensitization and allergy; the latter entails not only allergic sensitization, but also clinically relevant symptoms triggered by the culprit allergen.