Lack of Postprandial Peak in Brain-Derived Neurotrophic Factor in Adults with PraderWilli Syndrome

Context: Prader-Willi syndrome (PWS) is characterized by severe hyperphagia. Brain-derived neurotrophic factor (BDNF) and leptin are reciprocally involved in energy homeostasis. Objectives: To analyze the role of BDNF and leptin in satiety in genetic subtypes of PWS. Design: Experimental study. Sett...

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Hauptverfasser:	Bueno, Marta, Esteba-Castillo, Susanna, Novell, Ramon, Giménez-Palop, Olga, Coronas, Ramon, Gabau, Elisabeth, Corripio, Raquel, Baena Díez, Neus, Viñas-Jornet, Marina, Guitart, Maria, Torrents-Rodas, David, Deus Yela, Juan, Pujol Nuez, Jesús, Rigla Cros, Mercedes
Format:	Artikel
Sprache:	eng
Schlagworte:	Body mass index Childhood obesity Growth hormone Homeostasis Insulin Leptin Obesity Prader-Willi syndrome
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Zusammenfassung:	Context: Prader-Willi syndrome (PWS) is characterized by severe hyperphagia. Brain-derived neurotrophic factor (BDNF) and leptin are reciprocally involved in energy homeostasis. Objectives: To analyze the role of BDNF and leptin in satiety in genetic subtypes of PWS. Design: Experimental study. Setting: University hospital. Subjects: 90 adults: 30 PWS patients; 30 age-sex-BMI-matched obese controls; and 30 age-sex-matched lean controls. Interventions: Subjects ingested a liquid meal after fasting ≥10 hours. Main Outcome Measures: Leptin and BDNF levels in plasma extracted before ingestion and 30', 60', and 120' after ingestion. Hunger, measured on a 100-point visual analogue scale before ingestion and 60' and 120' after ingestion. Results: Fasting BDNF levels were lower in PWS than in controls (p = 0.05). Postprandially, PWS patients showed only a truncated early peak in BDNF, and their BDNF levels at 60' and 120' were lower compared with lean controls (p