Möglichkeiten und Grenzen der Antioxidans-Therapie entzündlich rheumatischer Erkrankungen mit hochdosiertem Vitamin E

Abstract The oxygen-derived molecules which are responsible for "oxidative stress" (· O -2 , 1 O 2 , H 2 O 2 , · OH) are mediators of inflammation potentially leading to cell- and tissue damage. The antiphlogistic therapy with antioxidants is based on this principle. The results of a placebo-controlled double blind study in patients with osteoarthritis demonstrate the antiphlogistic efficacy and excellent tolerance of highly dosed Vitamin E, a lipophilic antioxidant, The medical treatment of rheumatic inflammatory conditions by Vitamin E is compared and evaluated relative to already existing standard treatments.