Therapiestudie NHL-BFM 90 zur Behandlung maligner Non-Hodgkin-Lymphome bei Kindern und Jugendlichen - Teil 3: Eine Zwischenanalyse der Therapiegruppe B-NHL/B-ALL

Abstract The aims of trial NHL-BFM 90 for patients (pts) suffering from B-cell neoplasms are to prove wether: 1. treatment for pts with complete resection can be reduced from 3 to 2 therapy courses; 2. results for pts of stage III with large abdominal tumors can be improved by high dose (HD) chemotherapy; 3. survival for pts with incomplete initial response can be improved by therapy intensification; 4. intraventricularly applied CNS chemotherapy can improve the outcome for CNS positive pts. Therapy is stratified into 3 branches. Branch 1: completely resected; branch 2: not resected, extra-abdominal localization only or abdominal localization and LDH