Synthesis of 3-Trifluoromethyl- and 3-Perfluoroalkyl-Substituted 3-Aryloxy- and 3-Heteroaryloxypropenoic Acids and of the Cyclization Products, 2-Trifluoromethyl- and 2-Perfluoroalkyl-4H-chromen-4-ones

Abstract We describe a novel and simple method for the regio­specific synthesis of functionalized trifluoromethyl- and perfluoroalkyl-containing 4H-chromen-4-ones via the cyclization of substituted 3-aryloxy-3-perfluoroalkylpropenoic acids. The procedures give the final products in high yields, without any need for chromatographic purification, and no side products.