A C2-Symmetric Metallocene-Pyrrolidinopyridine Nucleophilic Catalyst for Asymmetric Synthesis

A C2-Symmetric Metallocene-Pyrrolidinopyridine Nucleophilic Catalyst for Asymmetric Synthesis

Abstract A C 2 -symmetric nucleophilic catalyst, (R,R)-3,5-diferrocenyl-4-(2′,5′-dimethylpyrrolidino)pyridine, was synthesised in three steps from commercially available (S,S)-hexane-2,5-diol. ­Application to the kinetic resolution of secondary alcohols (0.5 mol% loading) resulted in selectivity fac...

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Veröffentlicht in:Synlett 2007-03, Vol.2007 (5), p.0725-0728
Hauptverfasser: Nguyen, Huy V., Motevalli, Majid, Richards, Christopher J.
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creator Nguyen, Huy V.
Motevalli, Majid
Richards, Christopher J.
description Abstract A C 2 -symmetric nucleophilic catalyst, (R,R)-3,5-diferrocenyl-4-(2′,5′-dimethylpyrrolidino)pyridine, was synthesised in three steps from commercially available (S,S)-hexane-2,5-diol. ­Application to the kinetic resolution of secondary alcohols (0.5 mol% loading) resulted in selectivity factors (S) of up to 6.
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title A C2-Symmetric Metallocene-Pyrrolidinopyridine Nucleophilic Catalyst for Asymmetric Synthesis
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